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Changes are expected to become more evident after the second treatment takes full effect
What they did: They transected the quadriceps (front thigh) of rats and divided them into three groups: Control, no drugs Dexamethasone, a potent corticosteroid that is known to impair healing Dexamethasone + BPC-157 What they found: Dexamethasone group: 50 % worse healing than control (confirmed negative effect of steroids) Dexamethasone + BPC-157 group: healing at the level of controls without steroids Why it matters: This is a highly clinically relevant finding
By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, which thus remains available for recycling to NAD+ via the salvage pathway
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