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Peptides are often synthesized in small batches, which can drive up production costs compared to mass-produced pharmaceuticals

Increased extracellular glutamate in concert with glutaminolysis may contribute to detrimental excitotoxicity (Dixon et al., System -inhibition attenuates GSH levels, inactivates GPX4, and enhances lipid peroxidation (Dixon et al., While iron enhances lipid peroxidation via the non-enzymatic Fenton reaction, lipid peroxidation can also be catalyzed by specific non-heme, iron-containing lipoxygenases, such lipoxygenases also confer vulnerability to ferroptosis (Yang et al., During ferroptosis, cytosolic ferritin may undergo lysosomal breakdown (ferritinophagy) to further contribute to LIPferritinophagy appears to augment cysteine deficiency-induced ferroptosis (Gao et al., via hyperpolarized mitochondrial membrane potential (Gao et al., Mitochondria isolated from AD brains show increased accumulation of APP and -amyloid associated with reduced ability of mitochondria to import nuclear-encoded proteins and impaired cytochrome c oxidase activity (Devi et al., Evidence for Ferroptosis in AD Iron Chelators A 2-year Phase II clinical trial reported desferrioxamine, an iron chelator, attenuates cognitive decline in AD (Crapper McLachlan et al., Deferiprone is an orally active, brain penetrant iron-chelator, approved for use in -thalassemia, currently, undergoing a Phase II clinical trial in mild cognitive impairment (MCI) and AD (Deferiprone to Delay Dementiaclinicaltrials.gov identifier: NCT03235686

But Im not holding my breath