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[] While valproate-induced hyperammonemic encephalopathy (VHE) is itself a significant adverse effect, the presence of an underlying urea cycle disorder (UCD) increases the fatality rate
, ,
However, dedicated kidney outcome trials for GLP-1 receptor agonists remain limited, and further long-term studies are needed to better define their role in CKD management
The MAD evaluated doses ranging from 140 mg to 420 mg administered every 4 weeks on days 1, 29 and 57
I., Kwitko, I., Roehe, D
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