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semaglutide in direct comparison The clearest head-to-head trial between the two approved molecules for obesity is SURMOUNT-5 (Aronne et al., NEJM 2024, NEJMoa2416394)
Biomacromolecules 16(5):14891496
When a compound has no completed human trial, there is by definition no safety data in any subgroup no pregnancy data, no hepatic-impairment data, no interaction data with common metabolic or endocrine medications
These are usually gastrointestinal in nature and often subside as your body adjusts to the medication
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