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Harrison DJ, Kharbanda R, Cunningham DS, McLellan LI, Hayes JD
COMT is involved in the inactivation of catecholamine neurotransmitters such as epinephrine, norepinephrine, and dopamine, but also catecholestrogens and catechol drugs such as the antiParkinsons disease agent LDOPA and the antihypertensive methyldopa (Weinshilboum et al., 1999)
However, after ingestion, it may cause stomach discomfort, loss of appetite, nausea, diarrhea, and palpitations
The selective vulnerability in females led the authors to hypothesize a role for estrogen-linked mechanisms, although this was not tested
PMID: 26872976
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