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For instance, Ozempic is FDA-approved to treat type 2 diabetes, but it is frequently prescribed off-label for weight loss
doi:10.1046/j.1524-475X.1994.20406.x 9
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Mechanistically, HHcy promoted the activation of B cells, which secreted anti-beta 2 glycoprotein I (2GPI) antibodies that target GECs to increase the number of oxidized phospholipids, thus facilitating lipid peroxidation by activating PE synthases ethanolamine kinase 2 (ETNK2) and ethanolamine-phosphatecytidylyltransferase 2 (PCYT2) [262]
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