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Surgical interventions typically produce greater and more durable weight loss than pharmacotherapy alone and may be more appropriate than escalating to combination drug regimens with uncertain safety profiles

Cagrilintide rebuilt the molecule for duration and for obesity rather than glucose alone

Many patients struggle with weight management even when thyroid hormone levels are adequately replaced, suggesting that thyroid dysfunction may trigger persistent metabolic changes

Since the 1980s, GLP-1 medications have been a sort of holy grail for pharmaceutical companies

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