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Found's gradual titration protocol is specifically designed to minimize early side effects
The claims discussed reflect allegations raised in ongoing litigation and have not been adjudicated as legal conclusions
A 2014 pharmacokinetic study demonstrated that ketoconazole (a strong CYP3A4/P-gp inhibitor) increased apixaban AUC by approximately 100%, while rifampin (a strong inducer) decreased it by roughly 54% [1]
Martel J, Chang SH, Ko YF, Hwang TL, Young JD, Ojcius DM
from smoking related illnesses
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