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The biotic stress, such as drought, radiation, high salinity, extreme temperature, etc., triggers the synthesis and accumulation of betaine in plant cells ( 2.1 Trimethylamine-N-oxide and betaine in humans In humans, TMAO is mostly biosynthesized from the unabsorbed dietary constituents containing trimethylamine moiety such as choline (concentrated in egg yolk and liver) and L-carnitine (predominantly in red meat) through the activity of inhabitant bacteria of the human large intestine (Figure 2)
This decline correlates with decreased healing capacity and visible signs of skin aging
The story of how these compounds reached patients reflects decades of pharmaceutical innovation, regulatory approval, and real-world clinical outcomes that now benefit millions seeking sustainable weight management