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IGF-1 LR3 is one of the more potent activators of this process in the peptide space
The female mice (homozygous for Hba tm1(HBA)Tow and heterozygous for Hbb tm2(HBG1,HBB*)Tow and Hbb tm3(HBG1,HBB)Tow [h/h:: A / S ], sickle-cell trait mice) and male mice (homozygous for both Hba tm1(HBA)Tow and Hbb tm2(HBG1,HBB*)Tow [h/h:: S / S ], sickle SCD mice) were bred to generate SCD mice
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Chapter 12
It inhibits the tyrosinase enzyme, which is responsible for producing dark pigment, and shifts melanin production toward lighter tones
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