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other GLP-1 drugs: Side effect comparison Retatrutide has a similar side effect profile to other popular weight loss medications, such as semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro/Zepbound)
The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)
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Off-target effects GLP-1 receptors dont only exist in the digestive system theyre found in cells throughout the body, so it stands to reason that taking a GLP-1RA can have what scientists call off-target effects
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