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1 There are lots of animal studies. Animal studies are useful for mechanism and early safety signals, but they do not prove that a treatment works in humans

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Previous strategies to overcome these barriers, including dose optimization, image-guided planning, and combination systemic therapy, have achieved only incremental gains, leaving a significant unmet clinical need for innovative, tumor-targeted solutions [18, 19]

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Semaglutide, tirzepatide, and liraglutide are FDA-approved GLP-1 peptides that are clinically safe and effective for diabetes and weight management

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doi: 10.1016/j.resmic.2017.09.007 166

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