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PMID 25520039
Individuals with a history of allergies to certain substances should avoid these treatments due to the risk of severe reactions
Frontiers in Immunology, 13 , 934695
S-2P in the Janssen Ad26-vectored vaccine (Ad26.COV2.S) and in the Novavax protein-based vaccine (NVX-CoV2373) contains additional mutations at the S1S2 polybasic cleavage site from RRAR to SRAG or QQAQ to render it protease resistant, which helps to further stabilize the S protein in its pre-fusion conformation 96,97
Jiang Y, Wang X, Hu D
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