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Sensors and Actuators B: Chemical Volume 426, 1 March 2025, 137005 a Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, Key Laboratory of Emergency and Trauma, Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China b Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China c Department of Breast Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China Received 10 September 2024, Revised 5 November 2024, Accepted 24 November 2024, Available online 26 November 2024, Version of Record 29 November 2024.Full Text ighlights Glutathione-Activated Near-infrared II Fluorescent Probe (LJ-GSH) was developed