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Immunity 46 , 10891090 (2017)
In addition to counteracting BBB hyperpermeability by inhibiting the production of pro-inflammatory cytokines and ROS, VD has been shown to exert direct effects on ECs by up-regulating the expression of TJ proteins such as zonula occluden (ZO)-1 and claudin-5 while simultaneously down-regulating the levels of cell adhesion molecules such as ICAM-1 and VCAM-1, which collectively promotes the stabilization of the BBB [76]
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Vitamin B12 Deficiency The exact prevalence of Vitamin B12 deficiency remains unknown, but recent studies estimate between 1% and 20% of American adults have lower than optimal levels
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