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Efficacy and safety at 1mg have not been established in published trial data

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The recent studies on animal models of myocardial infarction, I/R, and diabetes or obesity-induced cardiac remodeling reported that DPP4i significantly reduced hypertrophy, left ventricular interstitial, and periarterial fibrosis as evidenced by decreased expression of TGF-, collagen, and components of cAMP/PKA/RhoA/ROCK2 pathway

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