Animal studies are consistent across multiple models
In erythroleukemia K562 cells, in addition to the above identified NRF2 binding ARE motif, there is also a strong association of active histone codes (such as H3K4Me3, H3K9Ac, H3K27Ac, H3K79Me2) upstream of the transcription start site (Supplementary Fig
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The accumulation factor at steady state is approximately 1.7-fold, meaning your trough level at steady state is about 1.7 times what it would be from a single dose
