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Patients with mild to moderate renal impairment generally do not require dose adjustment, but closer monitoring may be warranted, particularly for signs of gastrointestinal adverse effects that could lead to dehydration and worsening renal function
Diabetes Care , 47 (11), 18731888
Your receptors can adapt, and the effects will start to diminish if you overdo it
That evidence doesnt exist for it yet
This would be of special value for patients undergoing several week long radiotherapy during which prolonged fasting is no option
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