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CDC summarizes that guidance directly in its injection safety recommendations: "Once a multi-dose vial is opened (e.g., needle-punctured) the vial should be dated and discarded within 28 days unless the manufacturer states another date for that opened vial
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23 Pulmonary absorption gives instant presentation of levodopa to the absorptive membrane, which has a large surface area and low metabolic activity, 24 hence avoiding the variability in gastrointestinal absorption, poor pharmacokinetics, and consequent delayed on, or no on, or even dose failures with oral levodopa therapy
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PubMed Heffernan, M.A., Thorburn, A.W., Fam, B., Summers, R., Conway-Campbell, B., Waters, M.J., & Ng, F.M
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