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The establishment of the bodys normal microbial flora is shaped by localized chemical conditions, oxygen availability, host nutritional status, and the functional state of the immune system
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3 Initially approved by the FDA for diabetes treatment, semaglutide (Wegovy for weight loss) and tirzepatide (Zepbound for weight loss) have expanded into broader use
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The key cellular mediators of fibrosis are myofibroblasts, specialized cells characterized by expression of -SMA and a high capacity for producing and depositing ECM proteins, primarily collagen types I and III [85]
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