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Based on data from Phase 2 clinical trials including the pivotal randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) the most frequently reported sensations and side effects with retatrutide are largely gastrointestinal (GI) in nature
While it also mimics GLP-1, it goes a step further by targeting a second hormone receptor called GIP (glucose-dependent insulinotropic polypeptide)
Supports analytical review of receptor-pathway research materials within a strictly laboratory-focused context
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