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Patients on tirzepatide lost an average of 20.2% of their body weight over 72 weeks Patients on semaglutide lost an average of 13.7% of their body weight over the same period 47% more tirzepatide patients achieved 25% or greater body weight loss compared to semaglutide Tirzepatide also produced greater reductions in waist circumference across all dose comparisons A 2024 meta-analysis published in JAMA Internal Medicine analyzing real-world data from over 140,000 patients confirmed the same pattern: tirzepatide produced an average of 4.23 kg more weight loss than semaglutide across all doses and durations studied
Research-Backed Results A groundbreaking study with 1,961 adults showed that patients on semaglutide lost a lot of weight
[2] Zhang L, et al
Mounjaro Mounjaros dual agonist effect allows it to target both GLP-1 and GIP receptors
According to the drugs prescribing label, weight loss is typically the greatest in the first few weeks of treatment and then decreases in succeeding weeks
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