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By preventing this transfer, these agents can reduce the visibility of dark patches
However, there was also a distinct subset of genes specifically regulated in the DKO cells
doi: 10.1016/j.cmet.2017.07.011 77 DayJWOttawayNPattersonJTGelfanovVSmileyDGiddaJet al
In colorectal cancer, a high density of M2-like macrophages within the tumor stroma strongly correlates with reduced cancer-specific survival, while an elevated M1/M2 ratio indicates better prognosis, suggesting polarization status rather than overall density serves as a critical determinant of disease outcome (51)
