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Numerous studies showed that immune reactivity, inflammatory processes, and oxidative stress are actively involved in ALS pathogenesis (reviewed in [22, 23, 96, 102, 103])

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J Biol Chem 274:2505125060 Kawahara T, Quinn MT, Lambeth JD (2007) Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes

Originally identified on histones, Kla has been indicated to accumulate at gene promoters in response to diverse stimuli, including hypoxia, interferon-, LPS exposure and bacterial infections

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