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Incretins modulate pancreatic islet secretions as part of the "entero-insular axis," and their primary function is to regulate postprandial nutrient utilization and storage

Compounded GLP-1 medications occupy a different regulatory category than FDA-approved brand-name drugs, and individual results vary depending on adherence, dosage, diet, activity, and individual physiology

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However, these benefits were based on clinical endpoints and did not include direct measures of renal fibrosis, such as histology or fibrosis-specific biomarkers [55]