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Both use Solid-Phase Peptide Synthesis (SPPS) with synthetic amino acids the modern manufacturing standard
46 Overexpression of efflux transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) in tumors limits intracellular drug accumulation, while physical barriers such as the bloodbrain barrier constrain effective delivery to sites such as gliomas
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Alcohol Alcohol is known to lower glutathione levels
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