Ghashghaeinia M, Giustarini D, Koralkova P, Kberle M, Alzoubi K, Bissinger R, et al
reported that semaglutide accessed the brainstem, hypothalamus, and the dorsal half of the septal area, largely via small circumventricular organs, but it was not shown to cross the BBB [27]
Educating patients about recognizing early signs of low blood sugar and having strategies in place to address them, such as carrying glucose tablets, can further help in managing and preventing hypoglycemic events
A recent New England Journal of Medicine study showed that although both these new drugs are highly effective, tirzepatide was shown to be more effective for weight loss, possibly because of the combination of these two hormone agonists when compared to the single hormone agonist in semaglutide
Effect of Various Dosing Schedules on the Pharmacokinetics of Oral Semaglutide: A Randomised Trial in Healthy Subjects