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Recent findings Nonsurgical management options for Peyronie's disease include oral therapy, intra-lesional injections, and penile traction therapy

It has also been related to improving metabolic activity and lowering the risk of chronic diseases connected with PCOS [193]

This scarcity of literature highlights a research gap

Acknowledgements This research was supported by several grants: the KRIBB Research Initiative Program (KGM5242423), the Regional Innovation Strategy (RIS) program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (MOE) (2021RIS-002), and the Basic Science Research Program through the NRF, funded by the Ministry of Education, Science, and Technology (No

Future work will optimize non-invasive platforms (e.g., exosome-engineered carriers), as ICV remains a preclinical tool for mechanistic studies