Cross-sectional studies have shown that plasma and tissue glutathione concentrations decrease by approximately 10-15% per decade after age 45, and this decline is accelerated in conditions associated with chronic oxidative stress, including type 2 diabetes, cardiovascular disease, neurodegenerative diseases, HIV/AIDS, chronic liver disease, and chronic obstructive pulmonary disease (COPD) [2][3][10][11]
In rabbit experimental wounds, GHK-Cu application improved wound contraction and formation of granular tissue while elevating antioxidant enzyme activity and stimulating blood vessel growth
Journal of internal medicine 278, 16673 (2015)
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Adaikalakoteswari, A., Finer, S., Voyias, P