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Promote Lipolysis: It triggers the liver and fatty tissues to break down stored fat more aggressively for use as energy
Protein adequacy becomes critical during this phase
Also investigated for effects on fat oxidation and appetite modulation via ghrelin pathways
Retatrutide dosing in its Phase 2 trials explored several different titration schedules
This dual mechanism, reduced intake plus increased expenditure, explains why the Phase 2 data showed such dramatically higher weight loss percentages than any dual agonist trial
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