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Interestingly, Acrylate copolymer promoted a dual effect related to its time of exposure in MucilAir-HF model: a downregulation of some released inflammatory biomarkers at 30 min/day exposure (Figure 5), whereas it triggered an upregulation profile at 6h/day exposure (Supplementary Figure S1)

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Scharf, Tingjun Hou, Tianhua Zhou, Ming-Wei Wang, Yan Zhang URL: Published: Cell Research, 25 August 2021, volume 31, pages 11631175 This study reports four high-resolution structures of full-length melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein stimulated by different ligands, including the FDA-approved drug bremelanotide (Vyleesi)

Aqueous humor samples were collected at different time points, and CsA concentrations were measured using HPLC

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