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AHK-Cu, or Alanine-Histidine-Lysine-Copper, is a naturally occurring tripeptide complexed with copper that has been investigated for its role in activating copper-dependent enzymatic processes and modulating extracellular matrix proteins involved in tissue structure and repair

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The authors claimed the size change could promote the passive targeting via leaking vasculature (7150 nm) and meanwhile prevent homogenous leakage of SPIONs into normal tissues

doi: 10.1155/2019/3120391 179 SeongARYooJYChoiKLeeMHLeeYHLeeJet al