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J Clin Pharmacol

To assess the role of PBX3 in T cell migration, we knocked down PBX3 expression in tumor cells, co-cultured them with folate, and used the resulting supernatants to evaluate T cell motility (Fig

This reduces TUG1s ability to promote GDF15 ubiquitination and degradation, leading to higher GDF15 levels and activation of the nuclear factor E2-related factor 2 (NRF2) pathway, which exerts an inhibitory effect on ferroptosis [84]