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Local rashes most often come from three mechanisms: An immune response to the medication itself, sending histamine to the injection area Sensitivity to an inactive ingredient like a preservative or buffer in the formulation Mechanical trauma from the needle or a fast injection technique The immune explanation is straightforward: a neighborhood-level alarm that sends histamine and inflammatory signals, producing redness and itch
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Patients and healthcare professionals are reminded to report any suspected adverse reactions to medicines, including those experienced within clinical trials, via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk or through the Yellow Card app
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Winhusen T, Theobald J, Kaelber DC, Lewis D
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