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GLP-1 agonists during lactation Animal The concentration of exenatide in the milk of mice was 2.5% of the maternal plasma concentration
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10.7 Clinical Bottom Line GLP-1 receptor agonists: Do not inherently cause universal nutrient depletion May increase intake-related vulnerability Require structured dietary strategy Benefit from risk-based monitoring Should be accompanied by protein prioritisation Weight loss and nutritional adequacy are not mutually exclusive
First, a significant portion of the mechanistic support is derived from preclinical studies that utilize preventive or early intervention paradigms, which may not accurately reflect clinical treatment scenarios
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