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lucidum polysaccharides showed protective effects against acute liver injury induced by restraint stress in mice, evidenced by the improvement of GSH-Px, CAT, and SOD activities and a decrease in the activities of ALT and AST ( Agaricus blazei Murill polysaccharides alleviated liver and lung damages by improving the activities of SOD, GSH-Px, and CAT to relieve oxidative stress in organ dysfunction syndrome (MODS) mice (Table 1)

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However, studies using recombinant human IGF-1 (rhIGF-1), the native hormone that IGF-1 LR3 mimics more potently, provide the closest human evidence