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Safety : side-effect profiles are broadly similar, dominated by gastrointestinal symptoms such as nausea and diarrhoea

48% of adult participants receiving Wegovy lost at least 15% of their body weight compared to 5% of people receiving placebo

Here is the standard titration protocol: *Doses of 10mg and above are impractical with the 8mg/mL concentration due to volumes exceeding standard syringe capacity

Conflicts of Interest: From the study, several coauthors were Eli Lilly employees, and the sponsor designed and oversaw the trial, conducted site monitoring, data collation, and data analysis, with the last author also an employee of the sponsor

Since tirzepatide is administered once weekly, some patients anecdotally report that morning administration (rather than evening) may help minimize any potential sleep interference, though this has not been formally studied