sglt2 inhibitors vs glp 1 agonists SGLT-2 and GLP-1 Agonists: First-Line Therapy for Diabetes With Established Cardiovascular Disease Use of SGLT2 inhibitors or

Their ability to interrupt distinct segments of the vicious cycleNLRP3 inflammasome, NF-B, and Nrf2/GPX4provides a multi-target strategy for dismantling the cycle

Long-term use of metformin, proton pump inhibitors or H2 blockers , which can reduce B12 absorption over years

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While effective, this approach carries risks including supraphysiological hormone levels, suppression of natural GH production, and side effects such as fluid retention, joint pain, carpal tunnel syndrome, and potential insulin resistance

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