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This classification is closely linked to dosing frequency and differences in the degree of delayed gastric emptying [9]

Those can be signs of a medical problem

6.5 Diagnosis and differential diagnosis Based on clinical experience, the diagnostic criteria for neurological damage due to long-term NO inhalation include the following: A history of NO exposure, particularly frequent short-term inhalations

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This adaptation, while energy-conserving, manifests as increased cold sensitivity