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The decreased NADPH production results in insufficient reduction of oxidized glutathione disulfide (GSSG) and Prdx2, thus rendering the antioxidant system less effective (20)

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Elderly subjects exhibit a 94.6% lower glutathione concentration compared to younger adults, making efficient replenishment critical

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Targeting glutaminase and transaminase as a treatment for cancer GLS, which is highly expressed in cancer cells and plays a role in cancer progression, has been investigated extensively as a druggable target 41