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55 SakamotoK.YonokiY.KubotaY.KuwagataM.SaitoM.NakaharaT.et al (2006)
A total of 16 genes were identified as potential drivers of tumorigenesis, 6 of which were present in multiple samples, namely, NF1 (negative regulator of RAS pathway), mTOR (kinase, mediates response to stress), ERBB2 (EGF receptor), DAXX (apoptosis regulator and transcription repressor among other functions), MLL2 (histone methyltransferase), and NOTCH2 (regulator of cell fate)
WHO Drug Information
For type 2 diabetes, NICE guidance (NG28) recommends their use as second- or third-line therapy when metformin alone provides inadequate control, particularly in patients who would benefit from weight loss or where hypoglycaemia risk must be minimised
Among the 10 genes, the mRNA expression of ITPR1 and ADCY5 in CRC tissues was prominently lower than normal tissues (n = 20) (Figures 11A, B
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