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The targeting of Prx5 to mitochondria is highly conserved among species (Van der Eecken et al., 2011), and it has been associated with the protection of mtDNA from oxidative attacks (Banmeyer et al., 2005)

Am J Physiol Endocrinol Metab 306(2):E150E156

HIF-1alpha ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics

Many compounds currently being studied involve natural compounds for their anti-inflammatory and apoptotic mechanism through various signaling pathways in different MM cell lines, such as RPMI 8226, U266, etc

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