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doi: 10.1016/j.xcrm.2021.100371 175 HodikMAnagandulaMFuxeJKrogvoldLDahl-JrgensenKHytyHet al
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Redox control of liver function in health and disease
This signaling cascade induces CXCL1 secretion by gastric cancer cells, driving recruitment of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), CD8 T-cell exhaustion, and resistance to ICIs
A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published
