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7.1 Identification of gutliver axisrelated therapeutic targets The future studies to systematically identify key molecular targets involved in gutliver communication during cadmium exposure, including intestinal barrier regulators, bile acid signaling pathways, microbial metabolites, and inflammatory mediators, which may serve as potential intervention targets

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The proposed clinical trial endpoints are the resolution of steatohepatitis without worsening or liver fibrosis and/or improvement in liver fibrosis one stage or greater without worsening of steatohepatitis

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