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PLoS One 7(12):e52672
These include: Individuals with pernicious anemia , a condition that causes their bodies to be unable to adequately absorb vitamin B12
one of these cerebella also showed an almost complete loss of Purkinje cells from the Purkinje cell layer, as well as a marked loss of granular cells
This can make it harder for an egg to mature
In the search for UPS regulators to modulate PKA-pCREB levels in the brain, it was found that in the snail Aplysia , the ubiquitin C-terminal hydrolase (Ap-Uch, a homolog of vertebrate Uch-L1) enhances the degradation of the polyubiquitinated R subunit of PKA (Hegde et al., 1997)
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