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2026 Update: In the SURMOUNT-5 head-to-head trial, tirzepatide produced ~47% more weight loss than semaglutide over 72 weeks
Every temperature excursion above 8C reduces the remaining stability window even brief periods at room temperature accelerate degradation
Heat plus an opened vial is the worst combination
Studies have also suggested these semaglutide medications can reduce the risk of heart attack, stroke and chronic disease
Low electrolyte levels and poor hydration may cause lightheadedness, dizziness, or weakness
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