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Thyroid Tumors : In animal studies, semaglutide has been associated with an increased risk of thyroid tumors
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However, gastrointestinal adverse effects may lead to dehydration and acute kidney injury, particularly in patients with pre-existing renal disease, so close monitoring is advised
Understanding peptide safety helps set appropriate expectations before starting any new protocol
Theoretical and Class-Level Risks These have not been confirmed in cagrilintide trials but are flagged because they appear in related amylin or GLP-1 class data: pancreatitis, gallbladder disease, severe hypoglycemia (mainly when combined with insulin or sulfonylureas), and acute kidney injury secondary to dehydration from severe nausea or vomiting
