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there is the potential for: Ischemic injury due to potent vasoconstrictor action and tissue hypoxia Mild bradycardia, probably as a reflex result of a rise in blood pressure Arrhythmias Anxiety Transient headache Respiratory difficulty Pharmacokinetics: When released from nerve terminals, its actions are primarily (75%) terminated by neuronal reuptake Diffusion and degredation by extracellualr COMT contribute to a lesser extent

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It is estimated that PD affects at least 1% of the population over the age of 60 (Zafar and Yaddanapudi, 2023)

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B.RobinsonK

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Paolisso 1990)

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