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A study found that by examining the postmortem brain tissue of suicidal patients with depression, the astrocyte-specific methylation map in the genome showed that glutamate receptor ionotropic kainate 2 and brain-rich guanosine kinase-related protein, which are associated with depressive psychopathology, were less methylated 134
The medication may also affect other conditions such as pancreatic or kidney disease, and it can influence how other medications are absorbed
Elife 8 , e44235 (2019)
O3: MASH/NASH indication
Type 2 Diabetes With Obesity CagriSema REDEFINE 2 showed 13.7% weight loss with 73.5% of T2D patients achieving HbA1c of 6.5% or less, exceeding semaglutide's glycemic and weight results in T2D trials
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