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Interestingly, both Nrf2 and HO1 co-localized with reactive astrocytes, the major GSH suppliers for neighboring neurons, in the degenerating spinal cord of SOD1 G93A rats, and this was interpreted as a reactive attempt to prevent cell death

When the cold chain fails, the risks span multiple dimensions: Reduced therapeutic effect Temperature instability breaks down active ingredients, leading to decreased potency and inconsistent absorptionultimately reducing the medications effectiveness

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